As of 2013 The food service corporations Wendy's, Donatos Pizza, Bob Evans, Max & Erma's and White Castle along with nationally known companies Red Roof Inn, Rogue Fitness and Safelite are also based in the Columbus, Ohio metropolitan area.

An admirer of Benjamin Franklin, Sullivant chose to name his frontier village "Franklinton".

After Ohio achieved statehood in 1803, political infighting among prominent Ohio leaders led to the state capital moving from Chillicothe to Zanesville and back again.

It housed 26,000 troops and held up to 9,000 Confederate prisoners of war at Camp Chase, at what is now the Hilltop neighborhood of west Columbus.

Over 2,000 Confederate soldiers remain buried at the site, making it one of the North's largest Confederate cemeteries. By virtue of the Morrill Land-Grant Colleges Act, the Ohio Agricultural and Mechanical College (which became The Ohio State University) founded in 1870 on the former estate of William and Hannah Neil. By the end of the 19th century, Columbus was home to several major manufacturing businesses.

In the 1740s, Pennsylvania traders overran the territory until the French forcibly evicted them.

In the early 1750s the Ohio Company sent George Washington to the Ohio Country to survey.

Fighting for control of the territory in the French and Indian War (1754-1763) became part of the international Seven Years' War (1756-1763).

During this period the region routinely suffered turmoil, massacres and battles.

The legislature chose it as the capital over a number of other competitors, including Franklinton, Dublin, Worthington, and Delaware.

Prior to the state legislature's decision in 1812, Columbus did not exist. Named in honor of Christopher Columbus, the capital city was founded on February 14, 1812, on the "High Banks opposite Franklinton at the Forks of the Scioto most known as Wolf's Ridge." Nine people were elected to fill the various positions of Mayor, Treasurer, and several others.

Colonists from the East Coast moved in, but rather than finding an empty frontier, they encountered people of the Miami, Delaware, Wyandot, Shawnee, and Mingo nations, as well as European traders.